Using autochthonous transgenic mouse designs for inducible FGFR1 (JOCK1) and prostate-specific and ubiquitously indicated inducible -catenin (Pro-Cat and Ubi-Cat, respectively) and bigenic crosses between these lines (Pro-Cat JOCK1 and Ubi-Cat JOCK1), we describe WNT-induced synergistic acceleration of FGFR1-driven adenocarcinoma, associated with a pronounced fibroblastic reactive stroma activation surrounding prostatic intraepithelial neoplasia (mPIN) lesions found both in situ and reconstitution assays
Using autochthonous transgenic mouse designs for inducible FGFR1 (JOCK1) and prostate-specific and ubiquitously indicated inducible -catenin (Pro-Cat and Ubi-Cat, respectively) and bigenic crosses between these …